2022
Stoeger, T., Grant, R.A., McQuattie-Pimentel, A.C. et al. Aging is associated with a systemic length-associated transcriptome imbalance. Nat Aging 2, 1191–1206 https://doi.org/10.1038/s43587-022-00317-6 (2022)
Yoon, L., R. C. Botham, A. Verhelle, P. Sanz-Martinez, J. Xu, C. M. Cole, E. P. Tan, C. C. Chou, C. A. Cuoco, L. A. Massey, S. Labra, L. P. Elia, A. Ta, M. S. Ardejani, K. Lee, G. M. Kline, Q. Xiao, S. Cano-Franco, N. J. Lyang, W. C. Hou, A. Yu, S. Fox, Y. Ko, C. Wulkop-Gil, L. H. Ibrahim, S. Jiang, A. Meneses, L. T. Nelson, H. Peng, S. A. Lipton, M. J. Bollong, M. Hansen, R. I. Morimoto, H. M. Petrassi, R. L. Wiseman, E. T. Powers, S. Finkbeiner, D. Garza, D. Finley, M. A. Prado, I. Dikic, J. Frydman, K. A. Johnson, M. C. Silva, S. J. Haggarty, A. Stolz, S. E. Encalada, J. W. Kelly. mTOR inhibitor-independent Autophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes. bioRxiv 2022.09.29.509997; doi: https://doi.org/10.1101/2022.09.29.509997 (2022)
Sui, X., M. A. Prado, J. A. Paulo, S. P. Gygi, D. Finley, R. I. Morimoto. Global proteome metastability response in isogenic animals to missense mutations and polyglutamine expansions in aging. bioRxiv 2022.09.28.509812; doi: https://doi.org/10.1101/2022.09.28.509812 (2022)
The Proteostasis Consortium, Overall coordination, Elsasser s., L. P. Elia, R. I. Morimoto, E. T. Powers, Harvard Medical School group (analysis), D. Finley, University of California, San Francisco and Gladstone Institutes group I (chaperones, analysis), E. Mockler, L. Lima, S. Finkbeiner, University of California, San Francisco group II (chaperones, analysis), J. E. Gestwicki, Northwestern University group (chaperones, analysis), T. Stoeger, K. Cao, The Scripps Research Institute group (chaperones, endoplasmic reticulum proteostasis, mitochondrial proteostasis, analysis), D. Garza, J. W. Kelly, Stanford University group (chaperones, translation, mitochondrial proteostasis), M. Collier, T. K. Rainbolt, S. Taguwa, C. Chou, R. Aviner, N. Barbosa, F. Morales-Polanco, V. B. Masto, J. Frydman. A Comprehensive Enumeration of the Human Proteostasis Network. 1. Components of Translation, Protein Folding, and Organelle-Specific Systems. bioRxiv 2022.08.30.505920; doi: https://doi.org/10.1101/2022.08.30.505920 (2022)
Capano, L. S., C. Sato, E. Ficulle, A. Yu, K. Horie, N. R. Barthelemy, S. G. Fox, C. M. Karch, R. J. Bateman, H. Houlden, R. I. Morimoto, D. M. Holtzman, K. E. Duff, and A. S. Yoo. Recapitulation of Endogenous 4R Tau Expression Analogous to the Adult Brain in Directly Reprogrammed Human Neurons. Cell Stem Cell. 29: 918-932, doi: 10.1016/j.stem.2022.04.018 (2022).
Morimoto, R.I., and G.S. Budinger. Protein Folding Disorders. In: Harrison’s Principles of Internal Medicine (eds. J. Loscalzo, A. Fauci, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson), 21, Ch. 491 (2022).
Sala, A.J. and R.I. Morimoto. Protecting the Future: Balancing Proteostasis for Reproduction. Trends in Cell Biology. 32(3): 202-215, doi.org/10.1016/j.tcb.2021.09.009 (2022).
2021
Grant, R.A., Morales-Nebreda, L., Markov, N.S. et al. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia. Nature 590, 635–641. https://doi.org/10.1038/s41586-020-03148-w (2021)
Aman, Y., T. Schmauck-Medina, M. Hansen, R. I. Morimoto, A. K. Simon, I. Bjedov, K. Palikaras, A. Simonsen, T. Johansen, N. Tavernarakis, D. C. Rubinsztein, L. Partridge, G. Kroemer, J. Labbadia and E. F. Fang. Autophagy in Healthy Aging and Disease. Nature Aging 1: 634-650 (2021).
Lior, C., F. Hodge, E. A. De-Souza, D. Bourboulia, S. K Calderwood, D. David, D. A. Drummond, A. Edkins, R. I. Morimoto, V. Prahlad, O. Rechavi, L. Sistonen, M. Wilson, R. L. Wiseman, M. Zanetti, R. Taylor, R. Scherz-Shouval, and P.van Oosten-Hawle. The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3-4, 2021 FASEB J. 2021 Jun;35(6):e21631.
Watanabe, S., et al. Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis. Proceedings of the National Academy of Sciences 118(20): e2101100118. (2021)
McQuattie-Pimentel, A.C., Z. Ren, N. Joshi, S. Watanabe, T. Stoeger, M. Chi, Z. Lu, L. Sichizya, R. Piseaux, C.-I. Chen, S. Soberanes, P. A. Reyfman, J. M. Walter, K. R. Anekalla, J. M. Davis, C. E. Runyan, H. Abdala-Valencia, A. Y. Meliton, D. R. Winter, R. I. Morimoto, G. M. Mutlu, A. Bharat, H. Perlman, K. M. Ridge, N. S. Chandel, J. I. Sznajder, W. E. Balch, B. D. Singer, A. V. Misharin, and G. R. S. Budinger. The Lung Microenvironment Shapes a Dysfunctional Response of Alveolar Macrophages in Aging. J. Clinical Investigation. 131(4): e140299 (2021).
Sinnige, T., G. Meisl, T. C. T. Michaels, M. Vendruscolo, T. P.J. Knowles, and R. I. Morimoto. Kinetic Analysis Reveals that Independent Nucleation Events Determines the Progression of Protein Aggregation in C. elegans. Proc. Natl. Acad. Sci. U.S.A. 118(11)https://doi.org/10.1073/pnas.2021888118 (2021).
2020
Yamamoto YH, Kasai A, Omori H, et al. ERdj8 governs the size of autophagosomes during the formation process. J Cell Biol. 2020;219(8):e201903127. doi:10.1083/jcb.201903127
Sinnige T, Yu A, Morimoto RI. Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease. Adv Exp Med Biol. 2020;1243:53-68. doi:10.1007/978-3-030-40204-4_4
Sala AJ, Bott LC, Brielmann RM, Morimoto RI. Embryo integrity regulates maternal proteostasis and stress resilience. Genes Dev. 2020;34(9-10):678-687. doi:10.1101/gad.335422.119
2019
Ciryam, P, Antalek, M, Cid, F, Tartaglia, GG, Dobson, CM, Guettsches, A-K, Eggers, B, Vorerg, M, Marcus, K, Kley, RA, Morimoto, RI, Vendruscolo, M, Weihl, CC, A metastable subproteome underlies inclusion formation in muscle proteinopathies (2019), Acta Neuropathologica Communications, 7:197 https://doi.org/10.1186/s40478-019-0853-9
Dukovski, D, Villella, A, Bastos, C, King, R, Finley, D, Kelly, JW, Morimoto, RI, Hartl, FU, Munoz, B, Lee, P-S, Zecevic, M, Miller, JP, Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1- mediated regulation of CFTR mRNA, (2019) Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2020.02.006
Stoeger, T, Grant, RA, McQuattie-Pimentel, AC, Anekalla, K, Liu, SS, Tejedor-Navarro, H, Singer, BD, Abdala-Valencia, H, Schwake, M, Tetreault, M-P, Perlman, H, Balch, WE, Chandel, N, Ridge, K, Sznajder, JI, Morimoto, RI, Misharin, AV, Budinger, SGR, Amaral, LAN, Aging is associated with a systemic length-driven transcriptome imbalance (2019), bioRxiv, doi: http://dx.doi.org/10.1101/691154
Morimoto, RI, Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease, Cold Spring Harb Perspect Bio (2019), DOI:10.1101/cshperspect.a034074
Yu, A., Fox, SG, Cavallini, A, Kerridge, C, O’Neill, MJ, Wolak, J, Bose, S, Morimoto, RI, Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network, J Biol Chem (2019), http://www.jbc.org/cgi/doi/10.1074/jbc.RA119.007527
Grandjean, JMD, Plate, L, Morimoto, RI, Bollong, MJ, Powers, ET, Wiseman, RL, Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing, ACS Chemical Biology 2019 14 (4), 784-795 DOI: 10.1021/acschembio.9b00134
2018
Soberanes et al., Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis, Cell Metabolism (2018), https://doi.org/10.1016/j.cmet.2018.09.019.(2018).
Stoeger, T, Gerlach, M, Morimoto, RI and Amaral, LAN. Large-scale investigation of the reasons why potentially important genes are ignored. PLoS Biol 16(9): e2006643. https://doi. org/10.1371/journal.pbio.2006643 (2018).
2017
Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI. Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Cell Rep. 2017 Nov 7;21(6):1481-1494. doi: 10.1016/j.celrep.2017.10.038. (2017)
Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL Morimoto RI, Bukau B, Nillegoda NB. In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Aging Cell. DOI: 10.1111/acel.12686. Published online 10 October 2017.
Li J, Labbadia J, Morimoto RI. Rethinking HSF1 in Stress, Development, and Organismal Health. Trends Cell Biol. 2017 Sep 7. pii: S0962-8924(17)30139-3. doi: 10.1016/j.tcb.2017.08.002. [Epub ahead of print]. Review. (2017).
Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10. (2017).
Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M. Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease. PNAS USA. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26. (2017).
Sala AJ, Bott LC, Morimoto RI. Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol. 2017 Apr 11. pii: jcb.201612111. doi: 10.1083/jcb.201612111. [Epub ahead of print] Review. (2017).
Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ. Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proc Natl Acad Sci U S A. 2017 Apr 10. pii: 201613854. doi: 10.1073/pnas.1613854114. (2017).
2016
Winter, P., Brielmann, R., Timkovich, N., Navarro, H.,Teixeira-Castro, A., Morimoto R.I. and Amaral, L.A.N. A network approach to discerning the identities of C. elegans in a free moving population. Scientific Reports 6:34859, DOI: 10.1038 (2016).
Li, J., Chauve, L., Phelps, G., Brielmann, R. and Morimoto R.I. E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response. Genes and Development 30:2062-2075 (2016).
Ciryam, P., Kundra, R., Freer, R., Morimoto R.I., Dobson, C.M., and Vendruscolo, M. A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation. Proc Nat Acad Sci U S A 113(17) 4753-4758 (2016).
2015
Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva-Fernandes A, Neto MF, Brielmann RM, Bessa C, Duarte-Silva S, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, Silverman RB, Oliveira P, Morimoto RI, Maciel P. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain 2015: 138: 3221-3237.
Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B. Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nature 524, 247-251 (13 August 2015). Published online 05 August 2015.
Kirstein, J., D. Morito, T. Kakihana, M. Sugihara, A. Minnen, M.S. Hipp, C. Nussbaum-Krammer, F.U. Hartl, K. Nagata and R. I. Morimoto. Proteotoxic Stress and Ageing Triggers the Loss of Redox Homeostasis Across Cellular Compartments. The EMBO Journal. Pulished online July 29, 2015.
Labbadia, J. and R. I. Morimoto. Repression of the Heat Shock Response is a Programmed Event at the Onset of Reproduction. Molecular Cell 59, 1-12, http://dx.doi.org/10.1016/j.molcel.2015.06.0 (2015).
Brandvold, KR and RI Morimoto. The Chemical Biology of Molecular Chaperones-Implications for Modulation of Proteostasis. J Mol Biol (2015) 427, 2931- 2947. Review.
Walther, D.M., P. Kasturi, M. Zheng, S. Pinkert, G. Vecchi, P. Ciryam, R. I. Morimoto, C. M. Dobson, M. Vendruscolo, M. Mann, and F.U. Hartl. Widespread Proteome Remodeling and Aggregation in C. elegans. Cell 161, 919–932 May 7, 2015 a2015 Elsevier Inc. http://dx.doi.org/10.1016/j.cell.2015.03.032 (2015).
Ciryam, P., R. Kundra, R. I. Morimoto, C. M. Dobson, and M. Vendruscolo. Supersaturation is a Driving Force for Protein Aggregation in Neurodegenerative Diseases. Trends in Pharmacological Sciences, 36: 72-77, DOI:10.1016/j.tips.2014.12.004 (2015).
Labbadia, J., and R.I. Morimoto. The Biology of Proteostasis in Aging and Disease. Annual Reviews of Biochemistry, 84:32.1–32.30, doi: 10.1146/annurev-biochem-060614-033955 (2015).
Tatum, M.C., Ooi, F.K., Madhusudana, R.C., Chauve, L., Martinez-Velazquez, L.A., Steinbusch, H.W.M., Morimoto, R.I. and V. Prahlad. Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase, Current Biology (2015), http://dx.doi.org/10.1016/j.cub.2014.11.040
Nussbaum-Krammer, C. I., Neto, M. F., Brielmann, R. M., Pedersen, J. S., Morimoto, R. I. Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans. J. Vis. Exp. (95), e52321, doi:10.3791/52321 (2015).
2014
Roth, D.M., D.M. Hutt, J. Tong, M. Bouchecareilh, N. Wang, T. Seeley, J.F. Dekkers, J.M. Beekman, D. Garza, L. Drew, E. Masliah, R.I. Morimoto, W.E. Balch. Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding. PLOS Biology 12(11): e1001998. doi:10.1371/journal.pbio.1001998 (2014) .
Kennedy, B., S.L. Berger, A. Brunet, J. Campisi, AM Cuervo, E.S. Epel, C. Franceschi, G.J. Lithgow, R.I. Morimoto, J.E. Pessin, T.A. Rando, A. Richardson, E.E. Schadt, T. Wyss-Coray, F. Sierra. Geroscience: Linking Aging to Chronic Disease. Cell 159 (2014).
Brehme, M., C. Voisine, T. Rolland, S. Wachi, J.H. Soper, Y. Zhu, K. Orton, A. Villella, D. Garza, M. Vidal, H. Ge and R.I. Morimoto. A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease. Cell Reports (2014) http://dx.doi.org/10.1016/j.celrep.2014.09.042.
van Oosten-Hawle, P., and R.I. Morimoto. Organismal Control of Proteostasis by Cell Non-Autonomous Regulation and Transcellular Stress Signaling. Genes and Development 28: 1533-1543 (2014).
Trippier, P., K.T. Zhao, S.G. Fox, I. Schiefer, R. Benmohamed, J. Moran, D. Kirsch, R.I. Morimoto, and R. Silverman. Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis. ACS Chemical Neuroscience (2014).
Shibata, Y., and R.I. Morimoto. How the Nucleus Copes with Proteotoxic Stress. Current Biology 24 R463-474, DOI: 10.1016 (2014).
Ryno, L.M., J.C. Genereux, T. Naito, R.I. Morimoto, E.T. Powers, M.D. Shoulders, and R.L. Wiseman. Characterizing the Altered Cellular Proteomes Induced by the Stress-Independent Activation of Heat Shock Factor 1 to Physiologic Levels. ACS Chemical Biology (2014).
Morimoto, R.I., and A.M. Cuervo. Proteostasis and the Aging Proteome in Health and Disease. J. Gerontology: Biological Sciences and Medical Sciences 69(6) S33-38, DOI: 10.1093 (2014).
Yu, A., Y. Shibata, B. Shah, B. Calamini, D.C. Lo and R.I. Morimoto. Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proc Natl Acad Sci U S A.; 111(15):E1481-90. doi: 10.1073/pnas.1321811111. Epub 2014 Apr 1. (2014).
Labbadia, J. and R.I. Morimoto. Proteostasis and Longevity: When Does Aging Begin? F1000 Prime Reports 6:06 DOI: 10.12703 (2014).
Kitamura, A., N. Inada, H. Kubota, G. Matsumoto, M. Kinjo, R.I. Morimoto, and K. Nagata. Dysregulation of the Proteosome Increases the Toxicity of ALS-Linked Mutant SOD1. Genes to Cells DOI: 10.1111 (2014).
Nussbaum-Krammer, C., and R.I. Morimoto. Caenorhabditis elegans as a Model System for Cell Non-Autonomous Mechanisms in Protein Misfolding Diseases. Disease Models and Mechanisms 7: 31-39, DOI: 10.1242 (2014).
van Oosten-Hawle and R. I. Morimoto. Transcellular Chaperone Signaling: An Organismal Strategy for Integrated Cell Stress Responses. Journal of Experimental Biology 217: 129-136, DOI: 10.1242 (2014).
2013
Kirstein-Miles, J., and R.I. Morimoto. Ribosome-Associated Chaperones act as Proteostasis Sentinels. Cell Cycle. 12 (15): PMID: 23856581 (2013).
Bersuker, K., M. S. Hipp, B. Calamini, R.I. Morimoto, and R. R. Kopito. Heat Shock Response Activation Exacerbates Inclusion Body Formation in a Cellular Model of Huntington’s Disease J. Biol. Chem. 288 (33): 23633-23638, DOI:10.1074 (2013).
Ciryam, P., Tartaglia, G.G., Morimoto, R.I., Dobson, C.M., and Vendruscolo, M. Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins, Cell Reports (2013), http://dx.doi.org/10.1016/j.celrep.2013.09.043
Gidaevitz, T., Wang, N., Devaraj, T., Alexander-Floyd, J. and R.I. Morimoto. Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease. BMC Biology 2013, 11:100.
Silva, C.M., Amaral, M.D. and R.I. Morimoto. (2013). Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response. PLoS Genet 9(8): e1003711. doi:10.1371/journal.pgen.1003711.
Labbadia, J. and R.I. Morimoto. Huntington’s disease: underlying molecular mechanisms and emerging concepts. Trends Biochem Sci. 2013 Aug;38(8):378-85. doi: 10.1016/j.tibs.2013.05.003. Epub 2013 Jun 12. Review.
van Oosten-Hawle, P., Porter, R.S., and R.I. Morimoto. Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling. Cell 153, 1366–1378. Epub 6 June 2013.
Kirstein-Miles, J., Scior, A., Deuerling, E., Morimoto, R. (2013) The nascent polypeptide-associated complex is a key regulator of proteostasis. The EMBO Journal. 2013 May 15;32(10):1451-68. doi: 10.1038/emboj.2013.87. Epub 2013 Apr 19.
Guisbert E, Czyz DM, Richter K, McMullen PD, Morimoto RI (2013) Identification of a Tissue-Selective Heat Shock Response Regulatory Network. PLoS Genet 9(4): e1003466. doi:10.1371/journal.pgen.1003466. Epub 2013 Apr 18
Nussbaum-Krammer CI, Park K-W, Li L, Melki R, Morimoto RI (2013) Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans. PLoS Genet 9(3): e1003351. doi:10.1371/journal.pgen.1003351. Epub 2013 Mar 28.
Zhang Y, Benmohamed R, Huang H, Chen T, Voisine C, Morimoto RI, Kirsch DR, Silverman RB. Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. J Med Chem. 2013 Mar 28;56(6):2665-75. doi: 10.1021/jm400079a. Epub 2013 Mar 15.
2012
Calamini, B. and Morimoto R.I. Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation. Current Topics in Medicinal Chemistry. 2012, 12(22):2623-2640.
Ciryam P, Morimoto RI, Vendruscolo M, Dobson CM, O’Brien EP. In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E132-40. doi: 10.1073/pnas.1213624110. Epub 2012 Dec 19.
Rampelt H, Kirstein-Miles J, Nillegoda NB, Chi K, Scholz SR, Morimoto RI, Bukau B. Metazoan Hsp70 machines use Hsp110 to power protein disaggregation. EMBO J. 2012 Sep 18. doi: 10.1038/emboj.2012.264. [Epub ahead of print].
Zhang Y, Benmohamed R, Zhang W, Kim J, Edgerly CK, Zhu Y, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. ACS Med Chem Lett. 2012 May 22;3(7):584-587.
Beam, M, Silva, MC, Morimoto, RI. Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo. J Biol Chem. 2012 Jul 27;287(31):26136-45. Epub 2012 Jun 5.
Klaic, L, Morimoto, RI, Silverman, RB Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. ACS Chem Biol. 2012 May 18;7(5):928-37. Epub 2012 Mar 14.
Morimoto, RI. The Heat Shock Response: Systems Biology of Proteotoxic Stress Stress in Aging and Disease. Cold Spring Harb Symp Quant Biol. 2011;76:91-9. Epub 2012 Feb 27
Morimoto, RI. The Heat Shock Response:McMullen PD, Aprison EZ, Winter PB, Amaral LAN, Morimoto RI., Ruvinsky, I. (2012) Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress. PLoS Comput Biol 8(1): e1002338. doi:10.1371/journal.pcbi.1002338
2011
Silva MC, Fox S., Beam M, Thakkar H., Amaral MD and Morimoto RI. A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network. PLOS Genetics 7(12): e1002438. doi:10.1371/journal.pgen.1002438. 2011 Dec 29.
Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, Morimoto RI. Small molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8(2):185-96. doi: 10.1038/nchembio.763.
Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB. ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis. J. Med. Chem. 2012 Jan 12;55(1):515-27. doi: 10.1021/jm2014277. Epub 2011 Dec 22
Zhang W, Benmohamed R, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorg Med Chem. 2011 Nov 30. [Epub ahead of print]
Klaic L, Trippier PC, Mishra RK, Morimoto RI, Silverman RB. Remarkable stereospecific conjugate additions to the hsp90 inhibitor celastrol. J Am Chem Soc. 2011 Dec 14;133(49):19634-7. Epub 2011 Nov 21
Prahlad, V. and Morimoto, R.I. Neuronal Circuitry Regulates the Response of Caenorhabditis Elegans to Misfolded Proteins. Proc Natl Acad Sci USA. 108: 14204-14209 (2011)
Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaça JL, Dias N, Rodrigues P, Oliveira JF, Neves-Carvalho A, Morimoto RI, Maciel P. Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet. 20(15):2996-3009. Epub May 5 (2011)
Gidalevitz T, Prahlad V, Morimoto RI. The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms. Cold Spring Harb Perspect Biol. 2011 May 2. pii: cshperspect.a009704v1. doi: 10.1101/cshperspect.a009704. [Epub ahead of print]
Petre, I., C.L. Hyder, A. Mizera, A. Meinander, A. Mikhailov, R.I. Morimoto, L. Sistonen, J.E. Eriksson, and R-J. Back. A Simple Mass-Action Model for the Eukaryotic Heat Shock Response and its Mathematic Validation. Natural Computing, 10: 595-612, DOI: 10.1007/s11047-010-9216-y (2011)
Xia G, Benmohamed R, Kim J, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. J Med Chem. 2011 Apr 14;54(7):2409-21. Epub 2011 Mar 4
Morimoto RI, Driessen AJ, Hegde RS, Langer T. The life of proteins: the good, the mostly good and the ugly. Nat Struct Mol Biol. 2011 Jan;18(1):1-4
Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB. Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorg Med Chem. 2011 Jan 1;19(1):613-22. Epub 2010 Oct 30
Benmohamed R, Arvanites AC, Kim J, Ferrante RJ, Silverman RB, Morimoto RI, Kirsch DR. Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 Mar;12(2):87-96. Epub 2010 Nov 12
2010
Kikis EA, Gidalevitz T, Morimoto RI. Protein homeostasis in models of aging and age-related conformational disease. Adv Exp Med Biol. 2010;694:138-59. Review
Akerfelt, Malin, Morimoto, R.I. and Lea Sistonen. Heat Shock Factors: Integrators of Cell Stress, Development and Lifespan. Nat Rev Mol Cell Biol. 2010 Aug;11(8):545-55. Epub 2010 Jul 14. Review
McMullen, Patrick D., Morimoto, R.I. and Luis A. Nunes Amaral. Physically Grounded Approach for Estimating Gene Expression from Microarray Data. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13690-5. Epub 2010 Jul 19
Voisine C, Pedersen JS, Morimoto RI. Chaperone networks: tipping the balance in protein folding diseases. Neurobiol Dis. 2010 Oct;40(1):12-20. Epub 2010 May 21. Review
Kirstein-Miles, J. and R.I. Morimoto. Caenorhabditis elegans as a Model System to Study Intercompartmental Proteostasis: Interrelation of Mitochondrial Function, Longevity, and Neurodegenerative Diseases. Developmental Dynamics 239: 1529-1538 (2010)
Kirstein-Miles, J. and R.I. Morimoto. Peptides Signal Mitochondrial Stress. Cell Metabolism 11: 177-178 (2010).
Gidalevitz, T., E.A. Kikis, and R.I. Morimoto. A Cellular Perspective on Conformational Disease: The Role of Genetic Background and Proteostasis Networks. Current Opinions in Structural Biology 20: 23-32 (2010)
2009
Ben-Zvi, A., E.- Miller, and R.I. Morimoto. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. PNAS 106(35):14914-14919 (2009)
Powers, E.T., R.I. Morimoto, A. Dillin, J.W. Kelly, and W.E. Balch. Biological and Chemical Approaches to Diseases of Proteostasis Deficiency. Annual Reviews of Biochemistry 78:959-991 (2009)
Sharabi K, Hurwitz A, Simon AJ, Beitel GJ, Morimoto RI, Rechavi G, Sznajder JI, Gruenbaum Y. Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 106(10): 4024-29 (2009)
Gidalevitz, T., T. Krupinski, S. Garcia, and R.I. Morimoto. Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity. PLoS Genet 5(3): e1000399 (2009)
Westerheide, S.D., J. Anckar, S.M. Stevens, Jr., L. Sistonen, and R.I. Morimoto. Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1. Science 20: 1063-1066 (2009)
Prahlad, V., and R.I. Morimoto. Integrating the Stress Response: Lessons for Neurodegenerative Diseases from C. elegans. Trends in Cell Biology 19: 52-61 (2009). PMID: 19112021 [PubMed – as supplied by publisher]
2008
Morimoto R.I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Review. Genes and Development 22:1427-1438 (2008)
Prahlad, V., T. Cornelius and R.I. Morimoto. Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons. Science 320: 811-814 (2008)
Trott A., J.D. West, L. Klaic, S.D. Westerheide, R.B. Silverman, R.I. Morimoto, and K.A. Morano. Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule. Molecular Biology of the Cell 19: 1104-1112 (2008)
Balch, W.E., R.I. Morimoto, A. Dillin, and J.W. Kelly. Adapting proteostasis for disease intervention. Review. Science 319 (5865): 916-919 (2008)
2007
Garcia, S. M., M.O. Casanueva, M.C. Silva, M.D. Amaral, and R.I. Morimoto. Neuronal signaling modulates protein homeostasis in C. elegans postsynaptic muscle cells. Genes and Development 21: 3006-3016 (2007)
Zourlidou, A. T. Gidalevitz, M. Kristiansen , C. Landles, B. Woodman, D. J. Wells, D. S. Latchman, J. de Belleroche, S. J. Tabrizi, R. I. Morimoto and G. P. Bates. Hsp27 overexpression in the R6/2 mouse model of Huntington’s Disease: Chronic Neurodegeneration does not Induce Hsp27 Activation. Hum. Mol. Genet. Advance Access (2007)
Brignull, H.R., J.F. Morley, and R.I. Morimoto. The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging. (Ed. P. Csermly and L. Vigh) Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks, 594: 167-189, Landes Bioscience (2007)
2006
Finkbeiner, S., A.M. Cuervo, R.I. Morimoto and P.J. Muchowski. Disease-modifiying pathways in neurodegeneration. The Journal of Neuroscience 26(41): 10349-10357 (2006)
Brignull, H.R., J.F. Morley, S.M. Garcia, and R.I. Morimoto. Modeling Polyglutamine Pathogenesis in C. elegans. Methods in Enzymology 412: 256-282 (2006)
Morimoto, R.I. Stress, Aging and Neurodegenerative Disease. The New England Journal of Medicine 355(21): 2254-2255 (2006)
Kitamura, A., H. Kubota, C. Pack, G. Matsumoto, S. Hirayama, Y. Takahashi, H. Kimura., M. Kinjo, R. I. Morimoto and K. Nagata. Cytosolic Chaperonin Prevents Polyglutamine Toxicity with Altering the Aggregation State. Nature Cell Biology 8(10):1163-1175 (2006)
Brignull, H., F. Moore, S. Tang, and R. I. Morimoto. Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal Caenorhabditis elegans Model. The Journal of Neuroscience 26(29): 7597-7606 (2006)
Gidalevitz, T., A. Ben-Zvi, K. Ho, H. Brignull, and R. I. Morimoto. Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases . Science 311: 1471-1474 (2006)
Westerheide, S., T. Kawahara, K. Orton, and R.I. Morimoto. Triptolide, an Inhibitor of the Human Heat Shock Response that Enhances Stress-Induced Cell Death. J. Biol. Chem. 281: 9616-9622 (2006)
Matsumoto, G., S. Kim, and R.I. Morimoto. Huntingtin and mutant SOD1 form aggregate structures with distinct molecular properties in human cells. J Biol Chem. 281: 4477-4485 (2006)
Rieger TR, Morimoto RI, and V. Hatzimanikatis. Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo. Biophys J. 90: 886-95 (2006)
2005
Matsumoto, G., A. Stojanovic, C. Holmberg, S. Kim, and R.I. Morimoto. Structural Properties and Neuronal Toxicity of Amyotrophic Lateral Sclerosis-Associated Cu/Zn Superoxide Dismutase 1 Aggregates. J. Cell Biology 171: 75-85 (2005)
Westerheide, S., and R.I. Morimoto. Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation. J. Biol. Chem. 380: 33097-33100 (2005)
Rieger, T., R.I. Morimoto, and V. Hatzimanikatis. Mathematical Modeling of the Eukaryotic Heat Shock Response: Dynamics of the Hsp70 Promoter. Biophysical Journal 88: 1646-1658 (2005)
2004
Holmberg, C., K. Staniszewski, K. Mensah, A. Chavez, A. Matouschek, and R.I. Morimoto. Inefficient Degradation of Truncated Polyglutamine Proteins by the Proteasome. EMBO Journal 23: 4307-4318 (2004)
Westerheide, S., J. Bosman, B. Mbadugha, T. Kawahara, G. Matsumoto, W. Gu, S. Kim, J. Devlin, R. Silverman, and R.I. Morimoto. Celastrols as Inducers of the Heat Shock Response and Cytoprotection J. Biol. Chem. 279: 56053-60 (2004)
Solomon A, Bandhakavi S, Jabbar S, Shah R, Beitel GJ, Morimoto RI. Caenorhabditis elegans OSR-1 Regulates Behavioral and Physiological Responses to Hyperosmotic Environments. Genetics, 167: 161-170 (2004)
Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A, 101: 6403-6408 (2004)
Mosser DD, Morimoto RI. Molecular chaperones and the stress of oncogenesis. Oncogene, 23(16):2907-18 (2004).
Morley, J.F. and Morimoto, R. Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones. Mol Biol Cell. Feb;15:657-64 (2004)
2003
Colon-Ramos DA, Irusta PM, Gan EC, Olson MR, Song J, Morimoto RI, Elliott RM, Lombard M, Hollingsworth R, Hardwick JM, Smith GK, Kornbluth S. Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell. Oct;14:4162-72 (2003).
2002
Soojin Kim, Ellen A. A. Nollen, Kazunori Kitagawa, Vytautas P. Bindokas and Richard I. Morimoto. Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4: 826-831 (2002)
Morimoto, R.I. Dynamic Remodeling of Transcription Complexes by Molecular Chaperones. Cell 110: 1–20 (2002)
Morley J.F., Brignull H.R., Weyers J.J., Morimoto R.I. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. (2002)
Nollen EA, Morimoto RI. Chaperoning signaling pathways: molecular chaperones as stress-sensing ‘heat shock’ proteins. J Cell Sci. 115: 2809-16 (2002)
Jolly, C., L. Konecny, D.L. Grady, Y.A. Kutskova, J.J. Cotto, R.I. Morimoto, and C. Vourch. In vivo Binding of Active HSF1 to Human Chromosome 9 Heterochromatin During Stress. J. Cell Biology 156: 775-781 (2002)
Nollen, E.A.A. and R.I. Morimoto. Cellular and Molecular Response to Stress, Misfolded Proteins, and Diseases of Protein Misfolding (ed. T. Creighton), Encyclopedia of Molecular Medicine, p. 1553-1563, Wiley Press (2002)
2001
Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107:893-903 (2001)
Tai LJ, McFall SM, Huang K, Demeler B, Fox SG, Brubaker K, Radhakrishnan I, Morimoto RI. Structure-function analysis of the heat shock factor binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. J Biol Chem. (2001)
Mathew A, Mathur SK, Jolly C, Fox SG, Kim S, Morimoto RI. Stress-specific activation and repression of heat shock factors 1 and 2. Mol Cell Biol. 21: 7163-71 (2001)
Ahn SG, Liu PC, Klyachko K, Morimoto RI, Thiele DJ. The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress. Genes Dev.15: 2134-45 (2001)
Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20: 3800-10 (2001)
Carr, Menco, Yankova, Morimoto, and Farbman. Odorants as Cell-Type Specific Activators of a Heat Shock Response in the Rat Olfactory Mucosa. Journal of Comparative Neurology 432: 425-439 (2001)
Thress K, Song J, Morimoto RI, Kornbluth S. Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. EMBO J 1:1033-1041 (2001)
Song, J, Takeda M and Morimoto RI. Hsp70-Bag1 complex mediates a physiological stress signaling pathway that regulates Raf-1/ERK and cell growth. Nature Cell Biology 3: 276-282 (2001)
2000
Jolly C and Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. Journal of the National Cancer Institute 92:1564-1572, 2000
Mosser, D., Caron, A.W., Bourget, L., Meriin, A.B., Sherman, M.Y., Morimoto, R.I., and Massie, B. The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis. Molecular and Cellular Biology 20: 7146-7159 (2000)
Beere H, Wolf B, Mosser R, Klein K, Kuwana T, Morimoto R, Cohen G and Green D Heat shock protein 70 (Hsp70) inhibits apoptosis by preventing recruitment of procaspase-9 to aggregated Apaf-1. Nature Cell Bio. 2; 469-475, 2000
Satyal SH, Schmidt E, Kitagawa K, Sondheimer N, Lindquist S, Kramer JM, Morimoto RI. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci U S A 23;97(11):5750-5, 2000
Freeman BC, Michels A, Son, J, Kampinga H and Morimoto RI Analysis of molecular chaperone activities using in vitro and in vivo approaches. Methods in Molecular Biology, (ed. S. Keyse), p. 393-419, Humana Press, 2000
Mathew A, Shi Y, Jolly C, Morimoto RI. Analysis of the mammalian heat-shock response. Inducible gene expression and heat-shock factor activity. Methods Mol Biol 2000
Nollen EA. Brunsting JF. Song J. Kampinga HH. Morimoto RI. Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol:20(3):1083-8, 2000
1999
Carr VM, Morimoto RI, and Farbman AI. Development and further characterization of a small subclass of rat olfactory receptor neurons that shows immunoreactivity for the HSP70 heat shock protein. J Comp Neurol., 404:375-86, 1999
Super HJ. Hasenkrug KJ. Simmons S. Brooks DM. Konzek R. Sarge KD. Morimoto RI. Jenkins NA. Gilbert DJ. Copeland NG. Frankel W. Chesebro B. Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15. J Virol:73(9):7848-52, 1999
Cotto JJ and Morimoto RI. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors [Review]. Biochem. Soc. Symp., 64:105-118, 1999
Montgomery DL, Morimoto RI, Gierasch LM Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling. J Mol Biol:286(3):915-32, 1999
Morimoto RI. The Heat Shock Response: Regulation and Function of Molecular Chaperones. The Encyclopedia of Molecular Biology (ed. T. Creighton), p.1088-1098, Wiley Press, 1999
Jolly C. Morimoto RI. Stress and the cell nucleus: dynamics of gene expression and structure reorganization. Gene Expr:7(4-6):261-70, 1999
Wang SM. Khandekar JD. Kaul KL. Winchester DJ. Morimoto RI. A method for the quantitative analysis of human heat shock gene expression using a multiplex RT-PCR assay. Cell Stress & Chaperones
Jolly C. Vourc’h C. Robert-Nicoud M. Morimoto RI. Intron-independent association of splicing factors with active genes. Journal of Cell Biology. 14;145(6):1133-43, 1999
Jolly C. Usson Y. Morimoto RI. Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc National Academy of Science USA. 8;96(12):6769-74, 1999
Osipiuk J, Walsh MA, Freeman BC, Morimoto, RI, Joachimiak, A Structure of a new crystal form of human Hsp70 ATPase domain Acta Crystallographica, D55, 1105-1107, 1999
Melville MW. Tan SL. Wambach M. Song J. Morimoto RI. Katze MG. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. Journal of Biological Chemistry. 5;274(6):3797-803, 1999
1998
Morimoto, RI. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. (Review) Genes & Development, 12:3788-3796, 1998
Satyal, SH and Morimoto, R. I Biochemical events in the activation and attenuation of the heat shock transcriptional response. J. Biosci. 23: 303-311, 1998
Bimston D, Song J, Winchester D, Takayama S, Reed JC, Morimoto RI BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from sugstrate release EMBO 17: 6871-6878, 1998
Furukawa M, Uchiumi T, Nomoto M, Takano H, Morimoto RI, Naito S, Kuwano M, Kohno K The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIalpha gene by heat shock. J Biol Chem 1998
Morimoto RI, Santoro MG Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection Nat Biotechnol 1998 Sep;16(9):833-8
Mathew A and Morimoto, RI. Role of the heat-shock response in the life and death of proteins. Ann NY Acad Sci., 851:99-111, 1998
Mathew A, Mathur SK, Morimoto RI Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin- proteasome pathway Mol Cell Biol:18(9):5091-8, 1998
Tanabe M, Kawazoe Y, Takeda S, Morimoto RI, Nagata K, Nakai A Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. EMBO J 1998 Mar 16;17(6):1750-8
Shi Y, Mosser DD, Morimoto RI Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev., 12(5):654-66, 1998
Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI Negative regulation of the heat shock transcriptional response by HSBP1. Genes Dev 1998 Jul 1;12(13):1962-7
1997
Jolly C. Morimoto R. Robert-Nicoud M. Vourc’h C . HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites. Journal of Cell Science. 110 ( Pt 23):2935-41, 1997
Cotto J. Fox S. Morimoto R . HSF1 granules: a novel stress-induced nuclear compartment of human cells. Journal of Cell Science. 110 ( Pt 23):2925-34, 1997
Morimoto RI, Kline, MP, Bimston DN and Cotto, JJ. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochm., 32:17-29, 1997
Rallu M. Loones M. Lallemand Y. Morimoto R. Morange M. Mezger V . Function and regulation of heat shock factor 2 during mouse embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 94(6):2392-7, 1997
Takayama S. Bimston DN. Matsuzawa S. Freeman BC. Aime-Sempe C. Xie Z. Morimoto RI. Reed JC . BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO Journal. 16(16):4887-96, 1997
Kimura Y. Rutherford SL. Miyata Y. Yahara I. Freeman BC. Yue L. Morimoto RI. Lindquist S . Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes & Development. 11(14):1775-85, 1997
Kanei-Ishii C. Tanikawa J. Nakai A. Morimoto RI. Ishii S . Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science. 277(5323):246-8, 1997
Sriram M. Osipiuk J. Freeman B. Morimoto R. Joachimiak A . Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain. Structure. 5(3):403-14, 1997
Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI and Nagata K. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol 17:469-81, 1997
1996
Freeman BC. Toft DO. Morimoto RI . Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein P23. Science 274:1718-1720, 1996
Hansen S, Midgley CA, Lane DP, Freeman BC, Morimoto RI and Hupp TR. Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70. J Biol. Chem., 271: 30922-8, 1996
Morimoto RI. Kroeger PE. Cotto JJ . The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions. [Review] [116 refs] EXS. 77:139-63, 1996
Freeman BC. Morimoto RI . The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. EMBO Journal. 15(12):2969-79, 1996
Cotto JJ. Kline M. Morimoto RI . Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. Journal of Biological Chemistry. 271(7):3355-8, 1996
Marcuccilli CJ. Mathur SK. Morimoto RI. Miller RJ. Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock. Journal of Neuroscience. 16(2):478-85, 1996
1995
Nakai A. Kawazoe Y. Tanabe M. Nagata K. Morimoto RI. The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Molecular & Cellular Biology. 15(10):5268-78, 1995
Freeman BC. Myers MP. Schumacher R. Morimoto RI. Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO Journal. 14(10):2281-92, 1995
Bhattacharyya T. Karnezis AN. Murphy SP. Hoang T. Freeman BC. Phillips B. Morimoto RI. Cloning and subcellular localization of human mitochondrial hsp70. Journal of Biological Chemistry. 270(4):1705-10, 1995
Shi Y, Kroeger PE and Morimoto RI. The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive. Mol. Cell Biol., 15:4309-4318, 1995
Lee BS. Chen J. Angelidis C. Jurivich DA. Morimoto RI. Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage. PNAS 92(16):7207-11, 1995
Lee BS. Chen J. Angelidis C. Jurivich DA. Morimoto RI. Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage. PNAS 92(16):7207-11, 1995
1994
Carr VM. Murphy SP. Morimoto RI. Farbman AI. Small subclass of rat olfactory neurons with specific bulbar projections is reactive with monoclonal antibodies to the HSP70 heat shock protein. Journal of Comparative Neurology. 348(1):150-60, 1994
Kroeger PE. Morimoto RI. Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity. Molecular & Cellular Biology. 14(11):7592-603, 1994
Jurivich DA. Sistonen L. Sarge KD. Morimoto RI. Arachidonate is a potent modulator of human heat shock gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 91(6):2280-4, 1994
Sistonen L. Sarge KD. Morimoto RI. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Molecular & Cellular Biology. 14(3):2087-99, 1994.
Kanei-Ishii C. Yasukawa T. Morimoto RI. Ishii S. c-Myb-induced trans-activation mediated by heat shock elements without sequence-specific DNA binding of c-Myb. Journal of Biological Chemistry. 269(22):15768-75, 1994.
Sarge KD. Park-Sarge OK. Kirby JD. Mayo KE. Morimoto RI. Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biology of Reproduction. 50(6):1334-43, 1994.
Fawcett TW. Sylvester SL. Sarge KD. Morimoto RI. Holbrook NJ. Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. Journal of Biological Chemistry. 269(51):32272-8, 1994.
Mezger V. Rallu M. Morimoto RI. Morange M. Renard JP. Heat shock factor 2-like activity in mouse blastocysts. Developmental Biology. 166(2):819-22, 1994.
Mathur SK. Sistonen L. Brown IR. Murphy SP. Sarge KD. Morimoto RI. Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 91(18):8695-9, 1994.
Li WW. Sistonen L. Morimoto RI. Lee AS. Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element. Molecular & Cellular Biology. 14(8):5533-46, 1994.
1993
Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. [Review] Science. 259(5100):1409-10, 1993.
Sarge KD. Murphy SP. Morimoto RI. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress [published errata appear in Mol Cell Biol 1993 May;13(5):3122-3 and 1993 Jun;13(6):3838-9]. Molecular & Cellular Biology. 13(3):1392-407, 1993.
Kroeger PE. Sarge KD. Morimoto RI. Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element. Molecular & Cellular Biology. 13(6):3370-83, 1993.
KBeere HM. Morimoto RI. Hickman JA. Investigations of mechanisms of drug-induced changes in gene expression: N-methylformamide-induced changes in synthesis of the M(r) 72,000 constitutive heat shock protein during commitment of HL-60 cells to granulocyte differentiation. Cancer Research. 53(13):3034-9, 1993.
Nakai A. Morimoto RI. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Molecular & Cellular Biology. 13(4):1983-97, 1993.
1992
Sistonen L. Sarge KD. Phillips B. Abravaya K. Morimoto RI. Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Molecular & Cellular Biology. 12(9):4104-11, 1992.
Morimoto RI. Sarge KD. Abravaya K. Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses. [Review] Journal of Biological Chemistry. 267(31):21987-90, 1992.
Jurivich DA. Sistonen L. Kroes RA. Morimoto RI. Effect of sodium salicylate on the human heat shock response. Science. 255(5049):1243-5, 1992.
Morimoto RI. Transcription factors: positive and negative regulators of cell growth and disease. [Review] Current Opinion in Cell Biology. 4(3):480-7, 1992 .
Amici C. Sistonen L. Santoro MG. Morimoto RI. Antiproliferative prostaglandins activate heat shock transcription factor.Proceedings of the National Academy of Sciences of the United States of America. 89(14):6227-31, 1992.
Abravaya K. Myers MP. Murphy SP. Morimoto RI. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes & Development. 6(7):1153-64, 1992.
1991
Sarge KD. Zimarino V. Holm K. Wu C. Morimoto RI. Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes & Development. 5(10):1902-11, 1991.
Abravaya K. Phillips B. Morimoto RI. Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes & Development. 5(11):2117-27, 1991.
Phillips B. Abravaya K. Morimoto RI. Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses. Journal of Virology. 65(11):5680-92, 1991.
Kroes RA. Abravaya K. Seidenfeld J. Morimoto RI. Selective activation of human heat shock gene transcription by nitrosourea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 88(11):4825-9, 1991.
Watowich SS. Morimoto RI. Lamb RA. Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene. Journal of Virology. 65(7):3590-7, 1991.
Abravaya K. Phillips B. Morimoto RI. Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting. Molecular & Cellular Biology. 11(1):586-92, 1991.
Koskinen PJ. Sistonen L. Evan G. Morimoto R. Alitalo K. Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells. Journal of Virology. 65(2):842-51, 1991.
Morimoto RI. Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation. [Review] Cancer Cells. 3(8):295-301, 1991.
Phillips B. Morimoto RI. Transcriptional regulation of human hsp70 genes: relationship between cell growth, differentiation, virus infection, and the stress response. Results & Problems in Cell Differentiation. 17:167-87, 1991.
Sarge KD. Morimoto RI. Surprising features of transcriptional regulation of heat shock genes. [Review] Gene Expression. 1(3):169-73, 1991.
1990
Mosser DD. Kotzbauer PT. Sarge KD. Morimoto RI. In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proceedings of the National Academy of Sciences of the United States of America. 87(10):3748-52, 1990.
Williams GT. Morimoto RI. Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Molecular & Cellular Biology. 10(6):3125-36, 1990.
Alvares K. Carrillo A. Yuan PM. Kawano H. Morimoto RI. Reddy JK. Identification of cytosolic peroxisome proliferator binding protein as a member of the heat shock protein HSP70 family. Proceedings of the National Academy of Sciences of the United States of America. 87(14):5293-7, 1990.
Ovsenek N. Williams GT. Morimoto RI. Heikkila JJ. cis-acting sequences and trans-acting factors required for constitutive expression of a microinjected HSP70 gene after the midblastula transition of Xenopus laevis embryogenesis. Developmental Genetics. 11(1):97-109, 1990.
1989
Milarski KL. Morimoto RI. Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. Journal of Cell Biology. 109(5):1947-62, 1989.
Williams GT. McClanahan TK. Morimoto RI. E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Molecular & Cellular Biology. 9(6):2574-87, 1989.
Milarski KL. Welch WJ. Morimoto RI. Cell cycle-dependent association of HSP70 with specific cellular proteins. Journal of Cell Biology. 108(2):413-23, 1989.
Theodorakis NG. Zand DJ. Kotzbauer PT. Williams GT. Morimoto RI. Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response. Molecular & Cellular Biology. 9(8):3166-73, 1989.
1988
Theodorakis NG. Banerji SS. Morimoto RI. HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation. Journal of Biological Chemistry. 263(28):14579-85, 1988.
Schaefer EL. Morimoto RI. Theodorakis NG. Seidenfeld J. Chemical specificity for induction of stress response genes by DNA-damaging drugs in human adenocarcinoma cells. Carcinogenesis. 9(10):1733-8, 1988.
Mosser DD. Theodorakis NG. Morimoto RI. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Molecular & Cellular Biology. 8(11):4736-44, 1988.
Ferris DK. Harel-Bellan A. Morimoto RI. Welch WJ. Farrar WL. Frederick, MD.Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 85(11):3850-4, 1988.
Watowich SS. Morimoto RI. Complex regulation of heat shock- and glucose-responsive genes in human cells. Molecular & Cellular Biology. 8(1):393-405, 1988.
1987
Banerji SS. Laing K. Morimoto RI. Erythroid lineage-specific expression and inducibility of the major heat shock protein HSP70 during avian embryogenesis. Genes & Development. 1(9):946-53, 1987
Harrison GS. Drabkin HA. Kao FT. Hartz J. Hart IM. Chu EH. Wu BJ. Morimoto RI. Chromosomal location of human genes encoding major heat-shock protein HSP70. Somatic Cell & Molecular Genetics. 13(2):119-30, 1987
Morgan WD. Williams GT. Morimoto RI. Greene J. Kingston RE. Tjian R. Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Molecular & Cellular Biology. 7(3):1129-38, 1987
Theodorakis NG. Morimoto RI. Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Molecular & Cellular Biology. 7(12):4357-68, 1987
Moore M. Schaack J. Baim SB. Morimoto RI. Shenk T. Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells. Molecular & Cellular Biology. 7(12):4505-12, 1987
Wu BJ. Williams GT. Morimoto RI. Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein. Proceedings of the National Academy of Sciences of the United States of America. 84(8):2203-7, 1987
1986
Morimoto RI. Hunt C. Huang SY. Berg KL. Banerji SS. Organization, nucleotide sequence, and transcription of the chicken HSP70 gene. Journal of Biological Chemistry. 261(27):12692-9, 1986
Kingston RE. Cowie A. Morimoto RI. Gwinn KA. Binding of polyomavirus large T antigen to the human hsp70 promoter is not required for trans activation. Molecular & Cellular Biology. 6(9):3180-90, 1986
Banerji SS. Berg L. Morimoto RI. Transcription and post-transcriptional regulation of avian HSP70 gene expression. Journal of Biological Chemistry. 261(33):15740-5, 1986
Wu BJ. Kingston RE. Morimoto RI. Human HSP70 promoter contains at least two distinct regulatory domains. Proceedings of the National Academy of Sciences of the United States of America. 83(3):629-33, 1986
Milarski KL. Morimoto RI. Expression of human HSP70 during the synthetic phase of the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 83(24):9517-21, 1986
Wu BJ. Hurst HC. Jones NC. Morimoto RI. The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene. Molecular & Cellular Biology. 6(8):2994-9, 1986
1985
Wu BJ. Morimoto RI. Transcription of the human hsp70 gene is induced by serum stimulation. Proceedings of the National Academy of Sciences of the United States of America. 82(18):6070-4, 1985
Hunt C. Morimoto RI. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proceedings of the National Academy of Sciences of the United States of America. 82(19):6455-9, 1985
Wu B. Hunt C. Morimoto R. Structure and expression of the human gene encoding major heat shock protein HSP70. Molecular & Cellular Biology. 5(2):330-41, 1985
1984
Morimoto R. Fodor E. Cell-specific expression of heat shock proteins in chicken reticulocytes and lymphocytes. Journal of Cell Biology. 99:1316-23, 1984
Banerji SS. Theodorakis NG. Morimoto RI. Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes. Molecular & Cellular Biology 4:2437-48, 1984
